Interleukin 6
Appearance
mammalian protein found in Homo sapiens
ಇದರ ಭಾಗವಾಗಿದೆ
interleukin-6[೧೩]
four-helical cytokine-like, core[೧೩]
Interleukin-6/GCSF/MGF, conserved site, protein family[೧೪]
found in taxon
Homo sapiens[೧೧]
encoded by
IL6[೧೧]
molecular function
cell component
biological process
exact match
ಭಾಗವನ್ನು ಹೊಂದಿದೆ
Interleukin-6/GCSF/MGF, conserved site[೧೩]
Reference
- ↑ Freebase Data Dumps, ೨೮ ಅಕ್ಟೋಬರ್ 2013
- ↑ ೨.೦ ೨.೧ ೨.೨ ೨.೩ ೨.೪ NCBI Gene, ೩೦ ಮೇ 2020, 3569
- ↑ ೩.೦೦ ೩.೦೧ ೩.೦೨ ೩.೦೩ ೩.೦೪ ೩.೦೫ ೩.೦೬ ೩.೦೭ ೩.೦೮ ೩.೦೯ P05231, ೯ ಆಗಸ್ಟ್ 2016, UniProt, ಆಂಗ್ಲ
- ↑ Ensembl Release 99, ENSP00000385675
- ↑ Ensembl Release 99, ENSP00000258743
- ↑ Ensembl Release 99, ENSP00000384928
- ↑ Ensembl Release 99, ENSP00000385043
- ↑ Ensembl Release 99, ENSP00000385227
- ↑ Ensembl Release 99, ENSP00000385718
- ↑ Ensembl Release 99, ENSP00000405150
- ↑ ೧೧.೦ ೧೧.೧ ೧೧.೨ ೧೧.೩ UniProt, ೧೩ ನವೆಂಬರ್ 2019, P05231
- ↑ OpenAlex, ೨೬ ಜನವರಿ 2022, https://docs.openalex.org/download-snapshot/snapshot-data-format
- ↑ ೧೩.೦ ೧೩.೧ ೧೩.೨ InterPro Release 71.0, http://www.ebi.ac.uk/interpro/protein/P05231
- ↑ inferred from protein domain or family
- ↑ NAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, ೨೭ ಮಾರ್ಚ್ 2018, British Heart Foundation, Tumor necrosis factor alpha decreases, and interleukin-10 increases, the sensitivity of human monocytes to dexamethasone: potential regulation of the glucocorticoid receptor, GOA
- ↑ ೧೬.೦ ೧೬.೧ ೧೬.೨ ೧೬.೩ ೧೬.೪ ೧೬.೫ ೧೬.೬ ISS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, ೨೭ ಮಾರ್ಚ್ 2018, British Heart Foundation, GOA
- ↑ ೧೭.೦ ೧೭.೧ ೧೭.೨ ೧೭.೩ ೧೭.೪ IEA, ೨೭ ಮಾರ್ಚ್ 2018, P05231, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, UniProt
- ↑ ೧೮.೦ ೧೮.೧ ೧೮.೨ ೧೮.೩ IEA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, ೨೭ ಮಾರ್ಚ್ 2018, InterPro, GOA
- ↑ ೧೯.೦ ೧೯.೧ IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, ೨೭ ಮಾರ್ಚ್ 2018, British Heart Foundation, Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin, GOA
- ↑ ೨೦.೦ ೨೦.೧ ೨೦.೨ IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, ೨೭ ಮಾರ್ಚ್ 2018, British Heart Foundation, Structure and expression of cDNA and genes for human interferon-beta-2, a distinct species inducible by growth-stimulatory cytokines, GOA
- ↑ TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, ೨೭ ಮಾರ್ಚ್ 2018, Proteome Inc., Monocyte-derived human B-cell growth factor identified as interferon-beta 2 (BSF-2, IL-6), GOA
- ↑ ೨೨.೦ ೨೨.೧ ೨೨.೨ ೨೨.೩ IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, ೨೭ ಮಾರ್ಚ್ 2018, British Heart Foundation, Molecular cloning and expression of an IL-6 signal transducer, gp130, GOA
- ↑ ೨೩.೦ ೨೩.೧ ೨೩.೨ IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, ೨೭ ಮಾರ್ಚ್ 2018, British Heart Foundation, Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF, GOA
- ↑ TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, ೨೭ ಮಾರ್ಚ್ 2018, Proteome Inc., Loss of IL-6 receptor expression in cervical carcinoma cells inhibits autocrine IL-6 stimulation: abrogation of constitutive monocyte chemoattractant protein-1 production, GOA
- ↑ NAS, ೨೭ ಮಾರ್ಚ್ 2018, P05231, Marked cell-type-specific differences in glycosylation of human interleukin-6, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, UniProt
- ↑ IPI, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, ೨೭ ಮಾರ್ಚ್ 2018, British Heart Foundation, Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex, GOA
- ↑ IPI, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, ೨೭ ಮಾರ್ಚ್ 2018, IntAct protein interaction database, Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network, GOA
- ↑ IPI, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, ೨೭ ಮಾರ್ಚ್ 2018, IntAct protein interaction database, Detection of direct binding of human herpesvirus 8-encoded interleukin-6 (vIL-6) to both gp130 and IL-6 receptor (IL-6R) and identification of amino acid residues of vIL-6 important for IL-6R-dependent and -independent signaling, GOA
- ↑ IPI, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, ೨೭ ಮಾರ್ಚ್ 2018, IntAct protein interaction database, A human protein-protein interaction network: a resource for annotating the proteome, GOA
- ↑ IPI, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, ೨೭ ಮಾರ್ಚ್ 2018, IntAct protein interaction database, Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex, GOA
- ↑ IPI, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, ೨೭ ಮಾರ್ಚ್ 2018, IntAct protein interaction database, Structural Organization of a Full-Length gp130/LIF-R Cytokine Receptor Transmembrane Complex, GOA
- ↑ ೩೨.೦ ೩೨.೧ ೩೨.೨ ೩೨.೩ ೩೨.೪ TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, ೨೭ ಮಾರ್ಚ್ 2018, Reactome, GOA
- ↑ IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, ೨೭ ಮಾರ್ಚ್ 2018, British Heart Foundation, Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex, GOA
- ↑ IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, ೨೭ ಮಾರ್ಚ್ 2018, British Heart Foundation, Bacterial induction of TNF-alpha converting enzyme expression and IL-6 receptor alpha shedding regulates airway inflammatory signaling, GOA
- ↑ ೩೫.೦ ೩೫.೧ ೩೫.೨ IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, ೨೭ ಮಾರ್ಚ್ 2018, British Heart Foundation, Tumor necrosis factor alpha decreases, and interleukin-10 increases, the sensitivity of human monocytes to dexamethasone: potential regulation of the glucocorticoid receptor, GOA
- ↑ IC, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, ೨೭ ಮಾರ್ಚ್ 2018, British Heart Foundation, Interleukin 6 induces the expression of vascular endothelial growth factor, GOA
- ↑ IDA, ೨೭ ಮಾರ್ಚ್ 2018, P05231, BCL3 is induced by IL-6 via Stat3 binding to intronic enhancer HS4 and represses its own transcription, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, UniProt
- ↑ TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, ೨೭ ಮಾರ್ಚ್ 2018, British Heart Foundation, Platelet activation induced by interleukin-6: evidence for a mechanism involving arachidonic acid metabolism, GOA
- ↑ IC, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, ೨೭ ಮಾರ್ಚ್ 2018, British Heart Foundation, Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin, GOA
- ↑ ೪೦.೦ ೪೦.೧ NAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, ೨೭ ಮಾರ್ಚ್ 2018, British Heart Foundation, Bacterial induction of TNF-alpha converting enzyme expression and IL-6 receptor alpha shedding regulates airway inflammatory signaling, GOA
- ↑ IMP, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, ೨೭ ಮಾರ್ಚ್ 2018, British Heart Foundation, Induction of neuronal differentiation in PC12 cells by B-cell stimulatory factor 2/interleukin 6, GOA
- ↑ ೪೨.೦ ೪೨.೧ ೪೨.೨ ೪೨.೩ TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, ೨೭ ಮಾರ್ಚ್ 2018, British Heart Foundation, Bacterial induction of TNF-alpha converting enzyme expression and IL-6 receptor alpha shedding regulates airway inflammatory signaling, GOA
- ↑ ೪೩.೦ ೪೩.೧ NAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, ೨೭ ಮಾರ್ಚ್ 2018, British Heart Foundation, Cytokines promote Wnt signaling and inflammation and impair the normal differentiation and lipid accumulation in 3T3-L1 preadipocytes, GOA
- ↑ ೪೪.೦ ೪೪.೧ ೪೪.೨ ೪೪.೩ IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, ೨೭ ಮಾರ್ಚ್ 2018, Mouse Genome Informatics, Mitogen-activated protein kinases and ribosomal S6 protein kinases are involved in signaling pathways shared by interleukin-11, interleukin-6, leukemia inhibitory factor, and oncostatin M in mouse 3T3-L1 cells, GOA
- ↑ IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, ೨೭ ಮಾರ್ಚ್ 2018, British Heart Foundation, Synergistic activation of human T cells by interleukin 1 and interleukin 6, GOA
- ↑ ೪೬.೦ ೪೬.೧ ೪೬.೨ IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, ೨೭ ಮಾರ್ಚ್ 2018, British Heart Foundation, Novel path to activation of vascular smooth muscle cells: up-regulation of gp130 creates an autocrine activation loop by IL-6 and its soluble receptor, GOA
- ↑ ೪೭.೦ ೪೭.೧ IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, ೨೭ ಮಾರ್ಚ್ 2018, British Heart Foundation, Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells, GOA
- ↑ ೪೮.೦ ೪೮.೧ ೪೮.೨ ೪೮.೩ IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, ೨೭ ಮಾರ್ಚ್ 2018, British Heart Foundation, JAK/STAT but not ERK1/ERK2 pathway mediates interleukin (IL)-6/soluble IL-6R down-regulation of Type II collagen, aggrecan core, and link protein transcription in articular chondrocytes. Association with a down-regulation of SOX9 expression, GOA
- ↑ ೪೯.೦ ೪೯.೧ TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, ೨೭ ಮಾರ್ಚ್ 2018, British Heart Foundation, Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE), GOA
- ↑ IC, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, ೨೭ ಮಾರ್ಚ್ 2018, British Heart Foundation, Novel path to activation of vascular smooth muscle cells: up-regulation of gp130 creates an autocrine activation loop by IL-6 and its soluble receptor, GOA
- ↑ ೫೧.೦ ೫೧.೧ IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, ೨೭ ಮಾರ್ಚ್ 2018, British Heart Foundation, Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells, GOA
- ↑ ೫೨.೦ ೫೨.೧ IDA, ೨೭ ಮಾರ್ಚ್ 2018, P05231, Interleukin-6 suppression of neutrophil apoptosis is neutrophil concentration dependent, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, UniProt
- ↑ TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, ೨೭ ಮಾರ್ಚ್ 2018, British Heart Foundation, Gp130 activation by soluble interleukin-6 receptor/interleukin-6 enhances osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells, GOA
- ↑ IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, ೨೭ ಮಾರ್ಚ್ 2018, British Heart Foundation, Interleukin 6 induces the expression of vascular endothelial growth factor, GOA
- ↑ TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, ೨೭ ಮಾರ್ಚ್ 2018, British Heart Foundation, Interleukin-6 regulates pancreatic alpha-cell mass expansion, GOA
- ↑ IMP, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, ೨೭ ಮಾರ್ಚ್ 2018, British Heart Foundation, Interleukin-6 regulates pancreatic alpha-cell mass expansion, GOA
- ↑ IDA, ೨೭ ಮಾರ್ಚ್ 2018, P05231, Both Stat3-activation and Stat3-independent BCL2 downregulation are important for interleukin-6-induced apoptosis of 1A9-M cells, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, UniProt
- ↑ IEA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, ೨೭ ಮಾರ್ಚ್ 2018, Gene Ontology Consortium, GOA
- ↑ ೫೯.೦ ೫೯.೧ IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, ೨೭ ಮಾರ್ಚ್ 2018, British Heart Foundation, Interleukin-6 modulates the expression of the bone morphogenic protein receptor type II through a novel STAT3-microRNA cluster 17/92 pathway, GOA
- ↑ TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, ೨೭ ಮಾರ್ಚ್ 2018, Proteome Inc., Structure and expression of cDNA and genes for human interferon-beta-2, a distinct species inducible by growth-stimulatory cytokines, GOA
- ↑ IMP, ೨೭ ಮಾರ್ಚ್ 2018, P05231, Relationship between B7-H4, regulatory T cells, and patient outcome in human ovarian carcinoma, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, UniProt
- ↑ IDA, ೨೭ ಮಾರ್ಚ್ 2018, P05231, B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, UniProt
- ↑ ೬೩.೦ ೬೩.೧ IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, ೨೭ ಮಾರ್ಚ್ 2018, British Heart Foundation, STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation, GOA
- ↑ ೬೪.೦ ೬೪.೧ IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, ೨೭ ಮಾರ್ಚ್ 2018, British Heart Foundation, Interleukin-6 transcriptionally regulates prohibitin expression in intestinal epithelial cells, GOA
- ↑ IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, ೨೭ ಮಾರ್ಚ್ 2018, British Heart Foundation, IL-6 protects against hyperoxia-induced mitochondrial damage via Bcl-2-induced Bak interactions with mitofusins, GOA
- ↑ IMP, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, ೨೭ ಮಾರ್ಚ್ 2018, Mouse Genome Informatics, SASH1 is a scaffold molecule in endothelial TLR4 signaling, GOA
- ↑ ISS, ೨೭ ಮಾರ್ಚ್ 2018, P05231, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, UniProt
- ↑ ೬೮.೦ ೬೮.೧ IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, ೨೭ ಮಾರ್ಚ್ 2018, British Heart Foundation, Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2, GOA
- ↑ IC, http://www.ebi.ac.uk/QuickGO/annotations?protein=P05231&geneProductId=UniProtKB:P05231, ೨೭ ಮಾರ್ಚ್ 2018, British Heart Foundation, Interleukin-6 transcriptionally regulates prohibitin expression in intestinal epithelial cells, GOA
- ↑ Identifiers.org