ವಿಷಯಕ್ಕೆ ಹೋಗು

Scavenger receptor class B member 1

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mammalian protein found in Homo sapiens

External resources

Freebase ಐಡಿ
/m/03d01c0
Ensembl protein ID
ENSP00000261693[೧]
ENSP00000343795[೨]
ENSP00000414979[೩]
ENSP00000442862[೪]
ENSP00000443454[೫]
ENSP00000444851[೬]
Microsoft Academic ID
2779328381
UniProt protein ID
Q8WTV0[೭]
Transporter Classification Database ID
9.B.39.1.3[೮][೯]
RefSeq protein ID
NP_001076428[೧೦]
NP_005496[೧೦]
NP_001354910[೧೦]
NP_001354911[೧೦]
NP_001354912[೧೦]
NP_001354913[೧೦]
NP_001354914[೧೦]
NP_001354915[೧೦]
NP_001354916[೧೦]
NP_001354917[೧೦]
NP_001354918[೧೦]

ಉದಾಹರಣೆಗೆ

ಪ್ರೋಟೀನ್[೭]

ಇದರ ಭಾಗವಾಗಿದೆ

CD36/scavenger receptor class B member 1[೧೧]
Putative uncharacterized transport proteins[೧೨]

found in taxon

Homo sapiens[೭]

encoded by

SCARB1[೭]

molecular function

apolipoprotein binding[೧೩][೧೪]

determination method: IEA, IPI

protein homodimerization activity[೧೪]

determination method: IEA

virus receptor activity[೧೫]

determination method: IEA

transporter activity[೧೬]

determination method: TAS

high-density lipoprotein particle receptor activity[೧೭][೧೮]

determination method: IDA, IMP

phosphatidylserine binding[೧೯][೧೪]

determination method: ISS, IEA

apolipoprotein A-I binding[೧೩][೨೦]

determination method: IPI

lipopolysaccharide binding[೨೧]

determination method: IDA

low-density lipoprotein particle binding[೧೮]

determination method: IDA

1-phosphatidylinositol binding[೨೨]

determination method: TAS

protein binding[೨೩][೨೪][೨೫]

determination method: IPI

high-density lipoprotein particle binding[೧೪]

determination method: IEA

lipopolysaccharide immune receptor activity[೨೧]

determination method: IDA

amyloid-beta binding[೧೪]

determination method: IEA

scavenger receptor activity[೨೬]

determination method: TAS

cell component

ಕೋಶ ದ್ರವ[೧೪]

determination method: IEA

integral component of membrane[೧೫][೧೪]

determination method: IEA

endocytic vesicle membrane[೨೭]

determination method: TAS

intracellular membrane-bounded organelle[೨೮]

determination method: IDA

membrane[೧೫][೨೯]

determination method: IEA

plasma membrane[೨೭][೧೫][೧೮]

determination method: IDA, TAS, IEA

integral component of plasma membrane[೧೪]

determination method: IEA

cell surface[೩೦][೧೪]

determination method: ISS, IEA

lysosomal membrane[೩೧]

determination method: IDA

caveola[೩೨][೧೫][೧೪]

determination method: TAS, IEA

extracellular exosome[೩೩]

determination method: IDA

microvillus membrane[೧೪]

determination method: IEA

lysosomal membrane[೩೪]

determination method: HDA

extracellular exosome[೩೫]

determination method: HDA

biological process

cholesterol import[೩೬][೩೭][೧೭][೧೪]

determination method: ISS, IEA, IMP

positive regulation of triglyceride biosynthetic process[೧೯][೧೪]

determination method: ISS, IEA

regulation of phosphatidylcholine catabolic process[೧೯][೧೪]

determination method: ISS, IEA

recognition of apoptotic cell[೧೪][೧೮]

determination method: IDA, IEA

lipid transport[೧೪]

determination method: IEA

low-density lipoprotein particle clearance[೧೯][೧೪]

determination method: ISS, IEA

blood vessel endothelial cell migration[೧೪]

determination method: IEA

positive regulation of cholesterol storage[೧೮]

determination method: IDA

phospholipid transport[೧೯][೧೪]

determination method: ISS, IEA

cholesterol transport[೧೪]

determination method: IEA

wound healing[೩೮]

determination method: TAS

cholesterol catabolic process[೧೪]

determination method: IEA

receptor-mediated endocytosis[೨೭]

determination method: TAS

high-density lipoprotein particle remodeling[೧೯][೧೪]

determination method: ISS, IEA

positive regulation of endothelial cell migration[೩೮]

determination method: TAS

androgen biosynthetic process[೧೪]

determination method: IEA

vitamin transmembrane transport[೧೭]

determination method: IMP

positive regulation of nitric-oxide synthase activity[೩೯]

determination method: IDA

endothelial cell proliferation[೧೪]

determination method: IEA

lipopolysaccharide transport[೨೧]

determination method: IDA

cholesterol efflux[೩೬][೪೦][೧೪]

determination method: ISS, IEA, IMP

phagocytosis, recognition[೧೪]

determination method: IEA

viral entry into host cell[೪೧]

determination method: IEA

intestinal absorption[೧೪]

determination method: IEA

cholesterol homeostasis[೧೯][೧೪]

determination method: ISS, IEA

regulation of phagocytosis[೧೪][೪೨]

determination method: IC, IEA

adhesion of symbiont to host[೪೩]

determination method: IMP

viral process[೧೫]

determination method: IEA

detection of lipopolysaccharide[೨೧]

determination method: IDA

triglyceride homeostasis[೧೯][೧೪]

determination method: ISS, IEA

reverse cholesterol transport[೪೪][೧೪]

determination method: IEP, IEA

lipopolysaccharide-mediated signaling pathway[೪೧]

determination method: IEA

high-density lipoprotein particle clearance[೨೭][೧೮]

determination method: IDA, TAS

physically interacts with

Viroporin 3a[೪೫]

determination method: Affinity Capture-MS

Reference

  1. ↑ Ensembl Release 99, ENSP00000261693
  2. ↑ Ensembl Release 99, ENSP00000343795
  3. ↑ Ensembl Release 99, ENSP00000414979
  4. ↑ Ensembl Release 99, ENSP00000442862
  5. ↑ Ensembl Release 99, ENSP00000443454
  6. ↑ Ensembl Release 99, ENSP00000444851
  7. ↑ ೭.೦ ೭.೧ ೭.೨ ೭.೩ UniProt, ೧೩ ನವೆಂಬರ್ 2019, Q8WTV0
  8. ↑ Transporter Classification database, ೧೩ ಮಾರ್ಚ್ 2020
  9. ↑ Transporter Classification database, ೨೯ ಏಪ್ರಿಲ್ 2020
  10. ↑ ೧೦.೦೦ ೧೦.೦೧ ೧೦.೦೨ ೧೦.೦೩ ೧೦.೦೪ ೧೦.೦೫ ೧೦.೦೬ ೧೦.೦೭ ೧೦.೦೮ ೧೦.೦೯ ೧೦.೧೦ NCBI Gene, ೩೦ ಮೇ 2020, 949
  11. ↑ InterPro Release 71.0, http://www.ebi.ac.uk/interpro/protein/Q8WTV0
  12. ↑ 9.B.39.1.3, ೨ ಅಕ್ಟೋಬರ್ 2019, hierarchical database ID heuristic
  13. ↑ ೧೩.೦ ೧೩.೧ IPI, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0, ೮ ಏಪ್ರಿಲ್ 2019, British Heart Foundation, Apolipoprotein AII enrichment of HDL enhances their affinity for class B type I scavenger receptor but inhibits specific cholesteryl ester uptake, GOA
  14. ↑ ೧೪.೦೦ ೧೪.೦೧ ೧೪.೦೨ ೧೪.೦೩ ೧೪.೦೪ ೧೪.೦೫ ೧೪.೦೬ ೧೪.೦೭ ೧೪.೦೮ ೧೪.೦೯ ೧೪.೧೦ ೧೪.೧೧ ೧೪.೧೨ ೧೪.೧೩ ೧೪.೧೪ ೧೪.೧೫ ೧೪.೧೬ ೧೪.೧೭ ೧೪.೧೮ ೧೪.೧೯ ೧೪.೨೦ ೧೪.೨೧ ೧೪.೨೨ ೧೪.೨೩ ೧೪.೨೪ ೧೪.೨೫ ೧೪.೨೬ ೧೪.೨೭ ೧೪.೨೮ ೧೪.೨೯ ೧೪.೩೦ IEA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0, ೮ ಏಪ್ರಿಲ್ 2019, Ensembl genome database project, GOA
  15. ↑ ೧೫.೦ ೧೫.೧ ೧೫.೨ ೧೫.೩ ೧೫.೪ ೧೫.೫ IEA, ೮ ಏಪ್ರಿಲ್ 2019, Q8WTV0, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0, UniProt
  16. ↑ TAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0, ೮ ಏಪ್ರಿಲ್ 2019, Proteome Inc., Characterization of CLA-1, a human homologue of rodent scavenger receptor BI, as a receptor for high density lipoprotein and apoptotic thymocytes, GOA
  17. ↑ ೧೭.೦ ೧೭.೧ ೧೭.೨ IMP, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0, ೮ ಏಪ್ರಿಲ್ 2019, AgBase, Scavenger receptor class B, type I is expressed in porcine brain capillary endothelial cells and contributes to selective uptake of HDL-associated vitamin E, GOA
  18. ↑ ೧೮.೦ ೧೮.೧ ೧೮.೨ ೧೮.೩ ೧೮.೪ ೧೮.೫ IDA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0, ೮ ಏಪ್ರಿಲ್ 2019, British Heart Foundation, Characterization of CLA-1, a human homologue of rodent scavenger receptor BI, as a receptor for high density lipoprotein and apoptotic thymocytes, GOA
  19. ↑ ೧೯.೦ ೧೯.೧ ೧೯.೨ ೧೯.೩ ೧೯.೪ ೧೯.೫ ೧೯.೬ ೧೯.೭ ISS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0, ೮ ಏಪ್ರಿಲ್ 2019, British Heart Foundation, GOA
  20. ↑ IPI, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0, ೮ ಏಪ್ರಿಲ್ 2019, British Heart Foundation, Binding and internalization of lipopolysaccharide by Cla-1, a human orthologue of rodent scavenger receptor B1, GOA
  21. ↑ ೨೧.೦ ೨೧.೧ ೨೧.೨ ೨೧.೩ IDA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0, ೮ ಏಪ್ರಿಲ್ 2019, British Heart Foundation, Binding and internalization of lipopolysaccharide by Cla-1, a human orthologue of rodent scavenger receptor B1, GOA
  22. ↑ TAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0, ೮ ಏಪ್ರಿಲ್ 2019, British Heart Foundation, Characterization of CLA-1, a human homologue of rodent scavenger receptor BI, as a receptor for high density lipoprotein and apoptotic thymocytes, GOA
  23. ↑ IPI, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0, ೮ ಏಪ್ರಿಲ್ 2019, IntAct protein interaction database, A proteome-scale map of the human interactome network, GOA
  24. ↑ IPI, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0, ೮ ಏಪ್ರಿಲ್ 2019, IntAct protein interaction database, The human scavenger receptor class B type I is a novel candidate receptor for the hepatitis C virus, GOA
  25. ↑ IPI, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0, ೮ ಏಪ್ರಿಲ್ 2019, AgBase, The human scavenger receptor class B type I is a novel candidate receptor for the hepatitis C virus, GOA
  26. ↑ TAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0, ೮ ಏಪ್ರಿಲ್ 2019, ARUK-UCL, Scavenger receptor class B type I (SR-BI) mediates adhesion of neonatal murine microglia to fibrillar beta-amyloid, GOA
  27. ↑ ೨೭.೦ ೨೭.೧ ೨೭.೨ ೨೭.೩ TAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0, ೮ ಏಪ್ರಿಲ್ 2019, Reactome, GOA
  28. ↑ IDA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0, ೮ ಏಪ್ರಿಲ್ 2019, Human Protein Atlas, GOA
  29. ↑ IEA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0, ೮ ಏಪ್ರಿಲ್ 2019, InterPro, GOA
  30. ↑ ISS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0, ೮ ಏಪ್ರಿಲ್ 2019, British Heart Foundation, Scavenger receptor SR-BI in macrophage lipid metabolism, GOA
  31. ↑ IDA, ೯ ಮೇ 2017, Q8WTV0, Integral and associated lysosomal membrane proteins, GOA, http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q8WTV0, UniProt
  32. ↑ TAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0, ೮ ಏಪ್ರಿಲ್ 2019, British Heart Foundation, Binding and internalization of lipopolysaccharide by Cla-1, a human orthologue of rodent scavenger receptor B1, GOA
  33. ↑ IDA, ೯ ಮೇ 2017, Q8WTV0, MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis, GOA, http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q8WTV0, UniProt
  34. ↑ HDA, ೮ ಏಪ್ರಿಲ್ 2019, Q8WTV0, Integral and associated lysosomal membrane proteins, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0, UniProt
  35. ↑ HDA, ೮ ಏಪ್ರಿಲ್ 2019, Q8WTV0, MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0, UniProt
  36. ↑ ೩೬.೦ ೩೬.೧ ISS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0, ೮ ಏಪ್ರಿಲ್ 2019, British Heart Foundation, Scavenger receptor class B type I-mediated cholesteryl ester-selective uptake and efflux of unesterified cholesterol. Influence of high density lipoprotein size and structure, GOA
  37. ↑ IMP, ೮ ಏಪ್ರಿಲ್ 2019, Q8WTV0, Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0, UniProt
  38. ↑ ೩೮.೦ ೩೮.೧ TAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0, ೮ ಏಪ್ರಿಲ್ 2019, British Heart Foundation, Role of high-density lipoprotein and scavenger receptor B type I in the promotion of endothelial repair, GOA
  39. ↑ IDA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0, ೮ ಏಪ್ರಿಲ್ 2019, British Heart Foundation, High density lipoprotein binding to scavenger receptor, Class B, type I activates endothelial nitric-oxide synthase in a ceramide-dependent manner, GOA
  40. ↑ IMP, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0, ೮ ಏಪ್ರಿಲ್ 2019, AgBase, ABCA1 and scavenger receptor class B, type I, are modulators of reverse sterol transport at an in vitro blood-brain barrier constituted of porcine brain capillary endothelial cells, GOA
  41. ↑ ೪೧.೦ ೪೧.೧ IEA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0, ೮ ಏಪ್ರಿಲ್ 2019, Gene Ontology Consortium, GOA
  42. ↑ IC, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0, ೮ ಏಪ್ರಿಲ್ 2019, British Heart Foundation, Characterization of CLA-1, a human homologue of rodent scavenger receptor BI, as a receptor for high density lipoprotein and apoptotic thymocytes, GOA
  43. ↑ IMP, http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q8WTV0, ೯ ಮೇ 2017, British Heart Foundation, Entry of pseudotyped hepatitis C virus into primary human hepatocytes depends on the scavenger class B type I receptor, GOA
  44. ↑ IEP, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0, ೮ ಏಪ್ರಿಲ್ 2019, British Heart Foundation, Characterization of CLA-1, a human homologue of rodent scavenger receptor BI, as a receptor for high density lipoprotein and apoptotic thymocytes, GOA
  45. ↑ BioGRID, A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing, https://thebiogrid.org/news/227, ೧೯ ಏಪ್ರಿಲ್ 2020
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