ವಿಷಯಕ್ಕೆ ಹೋಗು

Scavenger receptor class B member 1

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mammalian protein found in Homo sapiens

External resources

Freebase ಐಡಿ
/m/03d01c0
Ensembl protein ID
ENSP00000261693[೧]
ENSP00000343795[೨]
ENSP00000414979[೩]
ENSP00000442862[೪]
ENSP00000443454[೫]
ENSP00000444851[೬]
Microsoft Academic ID
2779328381
UniProt protein ID
Q8WTV0[೭]
Transporter Classification Database ID
9.B.39.1.3[೮][೯]
RefSeq protein ID
NP_001076428[೧೦]
NP_005496[೧೦]
NP_001354910[೧೦]
NP_001354911[೧೦]
NP_001354912[೧೦]
NP_001354913[೧೦]
NP_001354914[೧೦]
NP_001354915[೧೦]
NP_001354916[೧೦]
NP_001354917[೧೦]
NP_001354918[೧೦]

ಉದಾಹರಣೆಗೆ

ಪ್ರೋಟೀನ್[೭]

ಇದರ ಭಾಗವಾಗಿದೆ

CD36/scavenger receptor class B member 1[೧೧]
Putative uncharacterized transport proteins[೧೨]

found in taxon

Homo sapiens[೭]

encoded by

SCARB1[೭]

molecular function

apolipoprotein binding[೧೩][೧೪]

determination method or standard: IEA, IPI

protein homodimerization activity[೧೪]

determination method or standard: IEA

virus receptor activity[೧೫]

determination method or standard: IEA

transporter activity[೧೬]

determination method or standard: TAS

high-density lipoprotein particle receptor activity[೧೭][೧೮]

determination method or standard: IDA, IMP

phosphatidylserine binding[೧೯][೧೪]

determination method or standard: ISS, IEA

apolipoprotein A-I binding[೧೩][೨೦]

determination method or standard: IPI

lipopolysaccharide binding[೨೧]

determination method or standard: IDA

low-density lipoprotein particle binding[೧೮]

determination method or standard: IDA

1-phosphatidylinositol binding[೨೨]

determination method or standard: TAS

protein binding[೨೩][೨೪][೨೫]

determination method or standard: IPI

high-density lipoprotein particle binding[೧೪]

determination method or standard: IEA

lipopolysaccharide immune receptor activity[೨೧]

determination method or standard: IDA

amyloid-beta binding[೧೪]

determination method or standard: IEA

scavenger receptor activity[೨೬]

determination method or standard: TAS

cell component

ಕೋಶ ದ್ರವ[೧೪]

determination method or standard: IEA

integral component of membrane[೧೫][೧೪]

determination method or standard: IEA

endocytic vesicle membrane[೨೭]

determination method or standard: TAS

intracellular membrane-bounded organelle[೨೮]

determination method or standard: IDA

membrane[೧೫][೨೯]

determination method or standard: IEA

plasma membrane[೨೭][೧೫][೧೮]

determination method or standard: IDA, TAS, IEA

integral component of plasma membrane[೧೪]

determination method or standard: IEA

cell surface[೩೦][೧೪]

determination method or standard: ISS, IEA

lysosomal membrane[೩೧]

determination method or standard: IDA

caveola[೩೨][೧೫][೧೪]

determination method or standard: TAS, IEA

extracellular exosome[೩೩]

determination method or standard: IDA

microvillus membrane[೧೪]

determination method or standard: IEA

lysosomal membrane[೩೪]

determination method or standard: HDA

extracellular exosome[೩೫]

determination method or standard: HDA

biological process

cholesterol import[೩೬][೩೭][೧೭][೧೪]

determination method or standard: ISS, IEA, IMP

positive regulation of triglyceride biosynthetic process[೧೯][೧೪]

determination method or standard: ISS, IEA

regulation of phosphatidylcholine catabolic process[೧೯][೧೪]

determination method or standard: ISS, IEA

recognition of apoptotic cell[೧೪][೧೮]

determination method or standard: IDA, IEA

lipid transport[೧೪]

determination method or standard: IEA

low-density lipoprotein particle clearance[೧೯][೧೪]

determination method or standard: ISS, IEA

blood vessel endothelial cell migration[೧೪]

determination method or standard: IEA

positive regulation of cholesterol storage[೧೮]

determination method or standard: IDA

phospholipid transport[೧೯][೧೪]

determination method or standard: ISS, IEA

cholesterol transport[೧೪]

determination method or standard: IEA

wound healing[೩೮]

determination method or standard: TAS

cholesterol catabolic process[೧೪]

determination method or standard: IEA

receptor-mediated endocytosis[೨೭]

determination method or standard: TAS

high-density lipoprotein particle remodeling[೧೯][೧೪]

determination method or standard: ISS, IEA

positive regulation of endothelial cell migration[೩೮]

determination method or standard: TAS

androgen biosynthetic process[೧೪]

determination method or standard: IEA

vitamin transmembrane transport[೧೭]

determination method or standard: IMP

positive regulation of nitric-oxide synthase activity[೩೯]

determination method or standard: IDA

endothelial cell proliferation[೧೪]

determination method or standard: IEA

lipopolysaccharide transport[೨೧]

determination method or standard: IDA

cholesterol efflux[೩೬][೪೦][೧೪]

determination method or standard: ISS, IEA, IMP

phagocytosis, recognition[೧೪]

determination method or standard: IEA

viral entry into host cell[೪೧]

determination method or standard: IEA

intestinal absorption[೧೪]

determination method or standard: IEA

cholesterol homeostasis[೧೯][೧೪]

determination method or standard: ISS, IEA

regulation of phagocytosis[೧೪][೪೨]

determination method or standard: IC, IEA

adhesion of symbiont to host[೪೩]

determination method or standard: IMP

viral process[೧೫]

determination method or standard: IEA

detection of lipopolysaccharide[೨೧]

determination method or standard: IDA

triglyceride homeostasis[೧೯][೧೪]

determination method or standard: ISS, IEA

reverse cholesterol transport[೪೪][೧೪]

determination method or standard: IEP, IEA

lipopolysaccharide-mediated signaling pathway[೪೧]

determination method or standard: IEA

high-density lipoprotein particle clearance[೨೭][೧೮]

determination method or standard: IDA, TAS

physically interacts with

Viroporin 3a[೪೫]

determination method or standard: Affinity Capture-MS

Reference

  1. ↑ Ensembl Release 99, ENSP00000261693
  2. ↑ Ensembl Release 99, ENSP00000343795
  3. ↑ Ensembl Release 99, ENSP00000414979
  4. ↑ Ensembl Release 99, ENSP00000442862
  5. ↑ Ensembl Release 99, ENSP00000443454
  6. ↑ Ensembl Release 99, ENSP00000444851
  7. ↑ ೭.೦ ೭.೧ ೭.೨ ೭.೩ UniProt, ೧೩ ನವೆಂಬರ್ 2019, Q8WTV0
  8. ↑ Transporter Classification database, ೧೩ ಮಾರ್ಚ್ 2020
  9. ↑ Transporter Classification database, ೨೯ ಏಪ್ರಿಲ್ 2020
  10. ↑ ೧೦.೦೦ ೧೦.೦೧ ೧೦.೦೨ ೧೦.೦೩ ೧೦.೦೪ ೧೦.೦೫ ೧೦.೦೬ ೧೦.೦೭ ೧೦.೦೮ ೧೦.೦೯ ೧೦.೧೦ NCBI Gene, ೩೦ ಮೇ 2020, 949
  11. ↑ InterPro Release 71.0, http://www.ebi.ac.uk/interpro/protein/Q8WTV0
  12. ↑ 9.B.39.1.3, ೨ ಅಕ್ಟೋಬರ್ 2019, hierarchical database ID heuristic
  13. ↑ ೧೩.೦ ೧೩.೧ British Heart Foundation, ೮ ಏಪ್ರಿಲ್ 2019, Apolipoprotein AII enrichment of HDL enhances their affinity for class B type I scavenger receptor but inhibits specific cholesteryl ester uptake, GOA, IPI, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0
  14. ↑ ೧೪.೦೦ ೧೪.೦೧ ೧೪.೦೨ ೧೪.೦೩ ೧೪.೦೪ ೧೪.೦೫ ೧೪.೦೬ ೧೪.೦೭ ೧೪.೦೮ ೧೪.೦೯ ೧೪.೧೦ ೧೪.೧೧ ೧೪.೧೨ ೧೪.೧೩ ೧೪.೧೪ ೧೪.೧೫ ೧೪.೧೬ ೧೪.೧೭ ೧೪.೧೮ ೧೪.೧೯ ೧೪.೨೦ ೧೪.೨೧ ೧೪.೨೨ ೧೪.೨೩ ೧೪.೨೪ ೧೪.೨೫ ೧೪.೨೬ ೧೪.೨೭ ೧೪.೨೮ ೧೪.೨೯ ೧೪.೩೦ Ensembl genome database project, ೮ ಏಪ್ರಿಲ್ 2019, GOA, IEA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0
  15. ↑ ೧೫.೦ ೧೫.೧ ೧೫.೨ ೧೫.೩ ೧೫.೪ ೧೫.೫ GOA, ೮ ಏಪ್ರಿಲ್ 2019, Q8WTV0, UniProt, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0, IEA
  16. ↑ Proteome Inc., ೮ ಏಪ್ರಿಲ್ 2019, Characterization of CLA-1, a Human Homologue of Rodent Scavenger Receptor BI, as a Receptor for High Density Lipoprotein and Apoptotic Thymocytes, GOA, TAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0
  17. ↑ ೧೭.೦ ೧೭.೧ ೧೭.೨ AgBase, ೮ ಏಪ್ರಿಲ್ 2019, Scavenger receptor class B, type I is expressed in porcine brain capillary endothelial cells and contributes to selective uptake of HDL-associated vitamin E, GOA, IMP, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0
  18. ↑ ೧೮.೦ ೧೮.೧ ೧೮.೨ ೧೮.೩ ೧೮.೪ ೧೮.೫ British Heart Foundation, ೮ ಏಪ್ರಿಲ್ 2019, Characterization of CLA-1, a Human Homologue of Rodent Scavenger Receptor BI, as a Receptor for High Density Lipoprotein and Apoptotic Thymocytes, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0
  19. ↑ ೧೯.೦ ೧೯.೧ ೧೯.೨ ೧೯.೩ ೧೯.೪ ೧೯.೫ ೧೯.೬ ೧೯.೭ British Heart Foundation, ೮ ಏಪ್ರಿಲ್ 2019, GOA, ISS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0
  20. ↑ British Heart Foundation, ೮ ಏಪ್ರಿಲ್ 2019, Binding and internalization of lipopolysaccharide by Cla-1, a human orthologue of rodent scavenger receptor B1, GOA, IPI, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0
  21. ↑ ೨೧.೦ ೨೧.೧ ೨೧.೨ ೨೧.೩ British Heart Foundation, ೮ ಏಪ್ರಿಲ್ 2019, Binding and internalization of lipopolysaccharide by Cla-1, a human orthologue of rodent scavenger receptor B1, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0
  22. ↑ British Heart Foundation, ೮ ಏಪ್ರಿಲ್ 2019, Characterization of CLA-1, a Human Homologue of Rodent Scavenger Receptor BI, as a Receptor for High Density Lipoprotein and Apoptotic Thymocytes, GOA, TAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0
  23. ↑ IntAct protein interaction database, ೮ ಏಪ್ರಿಲ್ 2019, A proteome-scale map of the human interactome network, GOA, IPI, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0
  24. ↑ IntAct protein interaction database, ೮ ಏಪ್ರಿಲ್ 2019, The human scavenger receptor class B type I is a novel candidate receptor for the hepatitis C virus, GOA, IPI, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0
  25. ↑ AgBase, ೮ ಏಪ್ರಿಲ್ 2019, The human scavenger receptor class B type I is a novel candidate receptor for the hepatitis C virus, GOA, IPI, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0
  26. ↑ ARUK-UCL, ೮ ಏಪ್ರಿಲ್ 2019, Scavenger receptor class B type I (SR-BI) mediates adhesion of neonatal murine microglia to fibrillar beta-amyloid, GOA, TAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0
  27. ↑ ೨೭.೦ ೨೭.೧ ೨೭.೨ ೨೭.೩ Reactome, ೮ ಏಪ್ರಿಲ್ 2019, GOA, TAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0
  28. ↑ Human Protein Atlas, ೮ ಏಪ್ರಿಲ್ 2019, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0
  29. ↑ InterPro, ೮ ಏಪ್ರಿಲ್ 2019, GOA, IEA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0
  30. ↑ British Heart Foundation, ೮ ಏಪ್ರಿಲ್ 2019, Scavenger receptor SR-BI in macrophage lipid metabolism, GOA, ISS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0
  31. ↑ Integral and associated lysosomal membrane proteins, GOA, ೯ ಮೇ 2017, Q8WTV0, UniProt, http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q8WTV0, IDA
  32. ↑ British Heart Foundation, ೮ ಏಪ್ರಿಲ್ 2019, Binding and internalization of lipopolysaccharide by Cla-1, a human orthologue of rodent scavenger receptor B1, GOA, TAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0
  33. ↑ MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis, GOA, ೯ ಮೇ 2017, Q8WTV0, UniProt, http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q8WTV0, IDA
  34. ↑ Integral and associated lysosomal membrane proteins, GOA, ೮ ಏಪ್ರಿಲ್ 2019, Q8WTV0, UniProt, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0, HDA
  35. ↑ MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis, GOA, ೮ ಏಪ್ರಿಲ್ 2019, Q8WTV0, UniProt, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0, HDA
  36. ↑ ೩೬.೦ ೩೬.೧ British Heart Foundation, ೮ ಏಪ್ರಿಲ್ 2019, Scavenger receptor class B type I-mediated cholesteryl ester-selective uptake and efflux of unesterified cholesterol. Influence of high density lipoprotein size and structure, GOA, ISS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0
  37. ↑ Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease, GOA, ೮ ಏಪ್ರಿಲ್ 2019, Q8WTV0, UniProt, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0, IMP
  38. ↑ ೩೮.೦ ೩೮.೧ British Heart Foundation, ೮ ಏಪ್ರಿಲ್ 2019, Role of high-density lipoprotein and scavenger receptor B type I in the promotion of endothelial repair, GOA, TAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0
  39. ↑ British Heart Foundation, ೮ ಏಪ್ರಿಲ್ 2019, High density lipoprotein binding to scavenger receptor, Class B, type I activates endothelial nitric-oxide synthase in a ceramide-dependent manner, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0
  40. ↑ AgBase, ೮ ಏಪ್ರಿಲ್ 2019, ABCA1 and scavenger receptor class B, type I, are modulators of reverse sterol transport at an in vitro blood-brain barrier constituted of porcine brain capillary endothelial cells, GOA, IMP, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0
  41. ↑ ೪೧.೦ ೪೧.೧ Gene Ontology Consortium, ೮ ಏಪ್ರಿಲ್ 2019, GOA, IEA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0
  42. ↑ British Heart Foundation, ೮ ಏಪ್ರಿಲ್ 2019, Characterization of CLA-1, a Human Homologue of Rodent Scavenger Receptor BI, as a Receptor for High Density Lipoprotein and Apoptotic Thymocytes, GOA, IC, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0
  43. ↑ British Heart Foundation, ೯ ಮೇ 2017, Entry of pseudotyped hepatitis C virus into primary human hepatocytes depends on the scavenger class B type I receptor, GOA, IMP, http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=Q8WTV0
  44. ↑ British Heart Foundation, ೮ ಏಪ್ರಿಲ್ 2019, Characterization of CLA-1, a Human Homologue of Rodent Scavenger Receptor BI, as a Receptor for High Density Lipoprotein and Apoptotic Thymocytes, GOA, IEP, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8WTV0
  45. ↑ BioGRID, A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing, https://thebiogrid.org/news/227, ೧೯ ಏಪ್ರಿಲ್ 2020
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