Prostaglandin-endoperoxide synthase 2
human enzyme involved in inflammation
ಇದರ ಭಾಗವಾಗಿದೆ
Prostaglandin G/H synthase 2[೭]
Haem peroxidase domain superfamily, animal type[೭]
Haem peroxidase superfamily[೭]
EGF-like domain, protein family[೮]
found in taxon
Homo sapiens[೬]
encoded by
PTGS2[೬]
molecular function
prostaglandin-endoperoxide synthase activity[೯][೧೭][೧೮][೧೯][೨೦][೨೧]
determination method: IEA, IDA, TAS
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen[೯][೧೯]
determination method: IEA, TAS
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen[೧೩]
determination method: IEA
cell component
biological process
positive regulation of platelet-derived growth factor production[೩೨][೧೩]
determination method: ISS, IEA
positive regulation of cell migration involved in sprouting angiogenesis[೩೪][೧೩]
determination method: ISS, IEA
positive regulation of transforming growth factor beta production[೩೪][೧೩]
determination method: ISS, IEA
positive regulation of vascular endothelial growth factor production[೩೪][೧೩]
determination method: ISS, IEA
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process[೧೩]
determination method: IEA
negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress[೧೩]
determination method: IEA
physically interacts with
EC enzyme number
1.14.99.1
exact match
ಭಾಗವನ್ನು ಹೊಂದಿದೆ
EGF-like domain[೭]
ಕಾಮನ್ಸ್ ವರ್ಗ
Cyclooxygenase 2
Reference
- ↑ Freebase Data Dumps, ೨೮ ಅಕ್ಟೋಬರ್ 2013
- ↑ NCBI Gene, ೩೦ ಮೇ 2020, 5743
- ↑ ೩.೦ ೩.೧ ೩.೨ ೩.೩ ೩.೪ ೩.೫ P35354, ೯ ಆಗಸ್ಟ್ 2016, UniProt, ಆಂಗ್ಲ
- ↑ Ensembl Release 99, ENSP00000356438
- ↑ Ensembl Release 99, ENSP00000454130
- ↑ ೬.೦ ೬.೧ ೬.೨ ೬.೩ UniProt, ೧೩ ನವೆಂಬರ್ 2019, P35354
- ↑ ೭.೦ ೭.೧ ೭.೨ ೭.೩ InterPro Release 71.0, http://www.ebi.ac.uk/interpro/protein/P35354
- ↑ inferred from protein domain or family
- ↑ ೯.೦ ೯.೧ ೯.೨ ೯.೩ TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P35354&geneProductId=UniProtKB:P35354, ೭ ನವೆಂಬರ್ 2018, Reactome, GOA
- ↑ ೧೦.೦೦ ೧೦.೦೧ ೧೦.೦೨ ೧೦.೦೩ ೧೦.೦೪ ೧೦.೦೫ ೧೦.೦೬ ೧೦.೦೭ ೧೦.೦೮ ೧೦.೦೯ ೧೦.೧೦ ೧೦.೧೧ ೧೦.೧೨ ೧೦.೧೩ ೧೦.೧೪ ೧೦.೧೫ IEA, ೯ ಮೇ 2019, P35354, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, UniProt
- ↑ ೧೧.೦ ೧೧.೧ ೧೧.೨ ೧೧.೩ ೧೧.೪ ISS, ೯ ಮೇ 2019, P35354, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, UniProt
- ↑ ೧೨.೦ ೧೨.೧ ೧೨.೨ ೧೨.೩ ೧೨.೪ ೧೨.೫ ೧೨.೬ ೧೨.೭ IEA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, ೯ ಮೇ 2019, InterPro, GOA
- ↑ ೧೩.೦೦ ೧೩.೦೧ ೧೩.೦೨ ೧೩.೦೩ ೧೩.೦೪ ೧೩.೦೫ ೧೩.೦೬ ೧೩.೦೭ ೧೩.೦೮ ೧೩.೦೯ ೧೩.೧೦ ೧೩.೧೧ ೧೩.೧೨ ೧೩.೧೩ ೧೩.೧೪ ೧೩.೧೫ ೧೩.೧೬ ೧೩.೧೭ ೧೩.೧೮ ೧೩.೧೯ ೧೩.೨೦ ೧೩.೨೧ ೧೩.೨೨ ೧೩.೨೩ ೧೩.೨೪ ೧೩.೨೫ ೧೩.೨೬ ೧೩.೨೭ ೧೩.೨೮ ೧೩.೨೯ ೧೩.೩೦ ೧೩.೩೧ ೧೩.೩೨ ೧೩.೩೩ ೧೩.೩೪ ೧೩.೩೫ ೧೩.೩೬ ೧೩.೩೭ ೧೩.೩೮ ೧೩.೩೯ ೧೩.೪೦ ೧೩.೪೧ ೧೩.೪೨ ೧೩.೪೩ ೧೩.೪೪ ೧೩.೪೫ ೧೩.೪೬ ೧೩.೪೭ ೧೩.೪೮ ೧೩.೪೯ ೧೩.೫೦ ೧೩.೫೧ ೧೩.೫೨ ೧೩.೫೩ ೧೩.೫೪ ೧೩.೫೫ ೧೩.೫೬ ೧೩.೫೭ ೧೩.೫೮ ೧೩.೫೯ ೧೩.೬೦ ೧೩.೬೧ ೧೩.೬೨ ೧೩.೬೩ ೧೩.೬೪ ೧೩.೬೫ ೧೩.೬೬ ೧೩.೬೭ ೧೩.೬೮ ೧೩.೬೯ ೧೩.೭೦ ೧೩.೭೧ ೧೩.೭೨ ೧೩.೭೩ ೧೩.೭೪ IEA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, ೯ ಮೇ 2019, Ensembl genome database project, GOA
- ↑ IPI, ೯ ಮೇ 2019, P35354, Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, UniProt
- ↑ IPI, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, ೯ ಮೇ 2019, Parkinsons Disease Gene Ontology Initiative, Caveolin-1 interacts with Derlin-1 and promotes ubiquitination and degradation of cyclooxygenase-2 via collaboration with p97 complex, GOA
- ↑ NAS, ೭ ನವೆಂಬರ್ 2018, P35354, Expression and localization of cyclooxygenase‐1 and ‐2 in human sporadic amyotrophic lateral sclerosis, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P35354&geneProductId=UniProtKB:P35354, UniProt
- ↑ ೧೭.೦ ೧೭.೧ IEA, ೭ ನವೆಂಬರ್ 2018, P35354, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P35354&geneProductId=UniProtKB:P35354, UniProt
- ↑ ೧೮.೦ ೧೮.೧ IEA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P35354&geneProductId=UniProtKB:P35354, ೭ ನವೆಂಬರ್ 2018, InterPro, GOA
- ↑ ೧೯.೦ ೧೯.೧ IEA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P35354&geneProductId=UniProtKB:P35354, ೭ ನವೆಂಬರ್ 2018, Ensembl genome database project, GOA
- ↑ IDA, ೭ ನವೆಂಬರ್ 2018, P35354, Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2, GOA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P35354&geneProductId=UniProtKB:P35354, UniProt
- ↑ IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P35354&geneProductId=UniProtKB:P35354, ೭ ನವೆಂಬರ್ 2018, British Heart Foundation, Human cyclooxygenase-2 cDNA, GOA
- ↑ ೨೨.೦ ೨೨.೧ NAS, ೯ ಮೇ 2019, P35354, Expression and localization of cyclooxygenase‐1 and ‐2 in human sporadic amyotrophic lateral sclerosis, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, UniProt
- ↑ IDA, ೯ ಮೇ 2019, P35354, Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, UniProt
- ↑ ೨೪.೦ ೨೪.೧ IDA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, ೯ ಮೇ 2019, British Heart Foundation, Human cyclooxygenase-2 cDNA, GOA
- ↑ IDA, ೯ ಮೇ 2019, P35354, Expression and localization of cyclooxygenase‐1 and ‐2 in human sporadic amyotrophic lateral sclerosis, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, UniProt
- ↑ TAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, ೯ ಮೇ 2019, Parkinsons Disease Gene Ontology Initiative, Caveolin-1 interacts with Derlin-1 and promotes ubiquitination and degradation of cyclooxygenase-2 via collaboration with p97 complex, GOA
- ↑ IDA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, ೯ ಮೇ 2019, Mouse Genome Informatics, Cellular localization of cyclooxygenase-1 and cyclooxygenase-2 in the normal mouse, rat, and human retina, GOA
- ↑ IDA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, ೯ ಮೇ 2019, Parkinsons Disease Gene Ontology Initiative, Caveolin-1 interacts with Derlin-1 and promotes ubiquitination and degradation of cyclooxygenase-2 via collaboration with p97 complex, GOA
- ↑ IDA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, ೯ ಮೇ 2019, Human Protein Atlas, GOA
- ↑ ೩೦.೦ ೩೦.೧ ೩೦.೨ ೩೦.೩ ೩೦.೪ ೩೦.೫ TAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, ೯ ಮೇ 2019, Reactome, GOA
- ↑ IEP, ೯ ಮೇ 2019, P35354, Hypoxia upregulates PGI-synthase and increases PGI₂ release in human vascular cells exposed to inflammatory stimuli, GOA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, UniProt
- ↑ ೩೨.೦ ೩೨.೧ ISS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, ೯ ಮೇ 2019, British Heart Foundation, GOA
- ↑ ೩೩.೦ ೩೩.೧ NAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, ೯ ಮೇ 2019, British Heart Foundation, Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes, GOA
- ↑ ೩೪.೦ ೩೪.೧ ೩೪.೨ ೩೪.೩ ೩೪.೪ ISS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, ೯ ಮೇ 2019, British Heart Foundation, Cyclooxygenase regulates angiogenesis induced by colon cancer cells, GOA
- ↑ ISS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, ೯ ಮೇ 2019, British Heart Foundation, Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes, GOA
- ↑ IEA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, ೯ ಮೇ 2019, Gene Ontology Consortium, GOA
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ೧೭ ಆಗಸ್ಟ್ 2016, 4139, ಆಂಗ್ಲ
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ೧೭ ಆಗಸ್ಟ್ 2016, 7124, ಆಂಗ್ಲ
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ೧೭ ಆಗಸ್ಟ್ 2016, 7141, ಆಂಗ್ಲ
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ೧೭ ಆಗಸ್ಟ್ 2016, 2892, ಆಂಗ್ಲ
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ೧೭ ಆಗಸ್ಟ್ 2016, 2714, ಆಂಗ್ಲ
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ೧೭ ಆಗಸ್ಟ್ 2016, 7185, ಆಂಗ್ಲ
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ೧೭ ಆಗಸ್ಟ್ 2016, 2896, ಆಂಗ್ಲ
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ೧೭ ಆಗಸ್ಟ್ 2016, 4194, ಆಂಗ್ಲ
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ೧೭ ಆಗಸ್ಟ್ 2016, 2713, ಆಂಗ್ಲ
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ೧೭ ಆಗಸ್ಟ್ 2016, 4795, ಆಂಗ್ಲ
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ೧೭ ಆಗಸ್ಟ್ 2016, 6661, ಆಂಗ್ಲ
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ೧೭ ಆಗಸ್ಟ್ 2016, 2897, ಆಂಗ್ಲ
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ೧೭ ಆಗಸ್ಟ್ 2016, 7219, ಆಂಗ್ಲ
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ೧೭ ಆಗಸ್ಟ್ 2016, 2593, ಆಂಗ್ಲ
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ೧೭ ಆಗಸ್ಟ್ 2016, 7220, ಆಂಗ್ಲ
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ೧೭ ಆಗಸ್ಟ್ 2016, 5230, ಆಂಗ್ಲ
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ೧೭ ಆಗಸ್ಟ್ 2016, 7401, ಆಂಗ್ಲ
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ೧೭ ಆಗಸ್ಟ್ 2016, 8976, ಆಂಗ್ಲ
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ೧೭ ಆಗಸ್ಟ್ 2016, 7252, ಆಂಗ್ಲ
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ೧೭ ಆಗಸ್ಟ್ 2016, 5239, ಆಂಗ್ಲ
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ೧೭ ಆಗಸ್ಟ್ 2016, 7270, ಆಂಗ್ಲ
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ೧೭ ಆಗಸ್ಟ್ 2016, 7273, ಆಂಗ್ಲ
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ೧೭ ಆಗಸ್ಟ್ 2016, 8741, ಆಂಗ್ಲ
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ೧೭ ಆಗಸ್ಟ್ 2016, 2893, ಆಂಗ್ಲ
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ೧೭ ಆಗಸ್ಟ್ 2016, 7298, ಆಂಗ್ಲ
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ೧೭ ಆಗಸ್ಟ್ 2016, 2894, ಆಂಗ್ಲ
- ↑ Open Targets Platform, ೧೪ ಆಗಸ್ಟ್ 2023, https://platform.opentargets.org/drug/CHEMBL154
- ↑ Open Targets Platform, ೧೪ ಆಗಸ್ಟ್ 2023, https://platform.opentargets.org/drug/CHEMBL1034
- ↑ Open Targets Platform, ೧೪ ಆಗಸ್ಟ್ 2023, https://platform.opentargets.org/drug/CHEMBL2107455
- ↑ Open Targets Platform, ೧೪ ಆಗಸ್ಟ್ 2023, https://platform.opentargets.org/drug/CHEMBL1071
- ↑ Open Targets Platform, ೧೪ ಆಗಸ್ಟ್ 2023, https://platform.opentargets.org/drug/CHEMBL1835207
- ↑ Open Targets Platform, ೧೪ ಆಗಸ್ಟ್ 2023, https://platform.opentargets.org/drug/CHEMBL25
- ↑ Open Targets Platform, ೧೪ ಆಗಸ್ಟ್ 2023, https://platform.opentargets.org/drug/CHEMBL521
- ↑ Open Targets Platform, ೧೪ ಆಗಸ್ಟ್ 2023, https://platform.opentargets.org/drug/CHEMBL166863
- ↑ Open Targets Platform, ೧೪ ಆಗಸ್ಟ್ 2023, https://platform.opentargets.org/drug/CHEMBL469
- ↑ Open Targets Platform, ೧೪ ಆಗಸ್ಟ್ 2023, https://platform.opentargets.org/drug/CHEMBL53292
- ↑ Open Targets Platform, ೧೪ ಆಗಸ್ಟ್ 2023, https://platform.opentargets.org/drug/CHEMBL139
- ↑ Open Targets Platform, ೧೪ ಆಗಸ್ಟ್ 2023, https://platform.opentargets.org/drug/CHEMBL622
- ↑ Open Targets Platform, ೧೪ ಆಗಸ್ಟ್ 2023, https://platform.opentargets.org/drug/CHEMBL1077
- ↑ Open Targets Platform, ೧೪ ಆಗಸ್ಟ್ 2023, https://platform.opentargets.org/drug/CHEMBL1297
- ↑ Open Targets Platform, ೧೪ ಆಗಸ್ಟ್ 2023, https://platform.opentargets.org/drug/CHEMBL898
- ↑ Open Targets Platform, ೧೪ ಆಗಸ್ಟ್ 2023, https://platform.opentargets.org/drug/CHEMBL435298
- ↑ Open Targets Platform, ೧೪ ಆಗಸ್ಟ್ 2023, https://platform.opentargets.org/drug/CHEMBL1200804
- ↑ Open Targets Platform, ೧೪ ಆಗಸ್ಟ್ 2023, https://platform.opentargets.org/drug/CHEMBL2103736
- ↑ Open Targets Platform, ೧೪ ಆಗಸ್ಟ್ 2023, https://platform.opentargets.org/drug/CHEMBL1201124
- ↑ Open Targets Platform, ೧೪ ಆಗಸ್ಟ್ 2023, https://platform.opentargets.org/drug/CHEMBL1200806
- ↑ Open Targets Platform, ೧೪ ಆಗಸ್ಟ್ 2023, https://platform.opentargets.org/drug/CHEMBL1200613
- ↑ Identifiers.org