Prostaglandin-endoperoxide synthase 2
ಗೋಚರ
human enzyme involved in inflammation
ಇದರ ಭಾಗವಾಗಿದೆ
Prostaglandin G/H synthase 2[೭]
Haem peroxidase domain superfamily, animal type[೭]
Haem peroxidase superfamily[೭]
EGF-like domain, protein family[೮]
found in taxon
Homo sapiens[೬]
encoded by
PTGS2[೬]
molecular function
prostaglandin-endoperoxide synthase activity[೯][೧೭][೧೮][೧೯][೨೦][೨೧]
determination method or standard: IEA, IDA, TAS
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen[೯][೧೯]
determination method or standard: IEA, TAS
prostaglandin-endoperoxide synthase activity[೧೦][೧೨][೧೩][೨೩][೨೪]
determination method or standard: IDA, IEA
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen[೧೩]
determination method or standard: IEA
cell component
biological process
positive regulation of synaptic transmission, glutamatergic[೧೩]
determination method or standard: IEA
positive regulation of platelet-derived growth factor production[೩೨][೧೩]
determination method or standard: ISS, IEA
prostaglandin biosynthetic process[೩೩][೧೧][೧೦][೧೨][೧೩]
determination method or standard: NAS, ISS, IEA
positive regulation of cell migration involved in sprouting angiogenesis[೩೪][೧೩]
determination method or standard: ISS, IEA
positive regulation of nitric oxide biosynthetic process[೩೪][೧೩]
determination method or standard: ISS, IEA
positive regulation of fibroblast growth factor production[೩೪][೧೩]
determination method or standard: ISS, IEA
positive regulation of transforming growth factor beta production[೩೪][೧೩]
determination method or standard: ISS, IEA
positive regulation of vascular endothelial growth factor production[೩೪][೧೩]
determination method or standard: ISS, IEA
positive regulation of brown fat cell differentiation[೩೫][೧೩]
determination method or standard: ISS, IEA
positive regulation of prostaglandin biosynthetic process[೩೩][೧೩]
determination method or standard: IEA, NAS
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process[೧೩]
determination method or standard: IEA
negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress[೧೩]
determination method or standard: IEA
physically interacts with
EC enzyme number
1.14.99.1
exact match
ಭಾಗವನ್ನು ಹೊಂದಿದೆ
EGF-like domain[೭]
ಕಾಮನ್ಸ್ ವರ್ಗ
Cyclooxygenase 2
Reference
- ↑ Freebase Data Dumps, ೨೮ ಅಕ್ಟೋಬರ್ 2013
- ↑ NCBI Gene, ೩೦ ಮೇ 2020, 5743
- ↑ ೩.೦ ೩.೧ ೩.೨ ೩.೩ ೩.೪ ೩.೫ P35354, ೯ ಆಗಸ್ಟ್ 2016, ಆಂಗ್ಲ, UniProt
- ↑ Ensembl Release 99, ENSP00000356438
- ↑ Ensembl Release 99, ENSP00000454130
- ↑ ೬.೦ ೬.೧ ೬.೨ ೬.೩ UniProt, ೧೩ ನವೆಂಬರ್ 2019, P35354
- ↑ ೭.೦ ೭.೧ ೭.೨ ೭.೩ InterPro Release 71.0, http://www.ebi.ac.uk/interpro/protein/P35354
- ↑ inferred from protein domain or family
- ↑ ೯.೦ ೯.೧ ೯.೨ ೯.೩ Reactome, ೭ ನವೆಂಬರ್ 2018, GOA, TAS, http://www.ebi.ac.uk/QuickGO/annotations?protein=P35354&geneProductId=UniProtKB:P35354
- ↑ ೧೦.೦೦ ೧೦.೦೧ ೧೦.೦೨ ೧೦.೦೩ ೧೦.೦೪ ೧೦.೦೫ ೧೦.೦೬ ೧೦.೦೭ ೧೦.೦೮ ೧೦.೦೯ ೧೦.೧೦ ೧೦.೧೧ ೧೦.೧೨ ೧೦.೧೩ ೧೦.೧೪ ೧೦.೧೫ GOA, ೯ ಮೇ 2019, P35354, UniProt, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, IEA
- ↑ ೧೧.೦ ೧೧.೧ ೧೧.೨ ೧೧.೩ ೧೧.೪ GOA, ೯ ಮೇ 2019, P35354, UniProt, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, ISS
- ↑ ೧೨.೦ ೧೨.೧ ೧೨.೨ ೧೨.೩ ೧೨.೪ ೧೨.೫ ೧೨.೬ ೧೨.೭ InterPro, ೯ ಮೇ 2019, GOA, IEA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354
- ↑ ೧೩.೦೦ ೧೩.೦೧ ೧೩.೦೨ ೧೩.೦೩ ೧೩.೦೪ ೧೩.೦೫ ೧೩.೦೬ ೧೩.೦೭ ೧೩.೦೮ ೧೩.೦೯ ೧೩.೧೦ ೧೩.೧೧ ೧೩.೧೨ ೧೩.೧೩ ೧೩.೧೪ ೧೩.೧೫ ೧೩.೧೬ ೧೩.೧೭ ೧೩.೧೮ ೧೩.೧೯ ೧೩.೨೦ ೧೩.೨೧ ೧೩.೨೨ ೧೩.೨೩ ೧೩.೨೪ ೧೩.೨೫ ೧೩.೨೬ ೧೩.೨೭ ೧೩.೨೮ ೧೩.೨೯ ೧೩.೩೦ ೧೩.೩೧ ೧೩.೩೨ ೧೩.೩೩ ೧೩.೩೪ ೧೩.೩೫ ೧೩.೩೬ ೧೩.೩೭ ೧೩.೩೮ ೧೩.೩೯ ೧೩.೪೦ ೧೩.೪೧ ೧೩.೪೨ ೧೩.೪೩ ೧೩.೪೪ ೧೩.೪೫ ೧೩.೪೬ ೧೩.೪೭ ೧೩.೪೮ ೧೩.೪೯ ೧೩.೫೦ ೧೩.೫೧ ೧೩.೫೨ ೧೩.೫೩ ೧೩.೫೪ ೧೩.೫೫ ೧೩.೫೬ ೧೩.೫೭ ೧೩.೫೮ ೧೩.೫೯ ೧೩.೬೦ ೧೩.೬೧ ೧೩.೬೨ ೧೩.೬೩ ೧೩.೬೪ ೧೩.೬೫ ೧೩.೬೬ ೧೩.೬೭ ೧೩.೬೮ ೧೩.೬೯ ೧೩.೭೦ ೧೩.೭೧ ೧೩.೭೨ ೧೩.೭೩ ೧೩.೭೪ Ensembl genome database project, ೯ ಮೇ 2019, GOA, IEA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354
- ↑ Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2, GOA, ೯ ಮೇ 2019, P35354, UniProt, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, IPI
- ↑ Parkinsons Disease Gene Ontology Initiative, ೯ ಮೇ 2019, Caveolin-1 interacts with Derlin-1 and promotes ubiquitination and degradation of cyclooxygenase-2 via collaboration with p97 complex, GOA, IPI, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354
- ↑ Expression and localization of cyclooxygenase‐1 and ‐2 in human sporadic amyotrophic lateral sclerosis, GOA, ೭ ನವೆಂಬರ್ 2018, P35354, UniProt, http://www.ebi.ac.uk/QuickGO/annotations?protein=P35354&geneProductId=UniProtKB:P35354, NAS
- ↑ ೧೭.೦ ೧೭.೧ GOA, ೭ ನವೆಂಬರ್ 2018, P35354, UniProt, http://www.ebi.ac.uk/QuickGO/annotations?protein=P35354&geneProductId=UniProtKB:P35354, IEA
- ↑ ೧೮.೦ ೧೮.೧ InterPro, ೭ ನವೆಂಬರ್ 2018, GOA, IEA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P35354&geneProductId=UniProtKB:P35354
- ↑ ೧೯.೦ ೧೯.೧ Ensembl genome database project, ೭ ನವೆಂಬರ್ 2018, GOA, IEA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P35354&geneProductId=UniProtKB:P35354
- ↑ Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2, GOA, ೭ ನವೆಂಬರ್ 2018, P35354, UniProt, http://www.ebi.ac.uk/QuickGO/annotations?protein=P35354&geneProductId=UniProtKB:P35354, IDA
- ↑ British Heart Foundation, ೭ ನವೆಂಬರ್ 2018, Human cyclooxygenase-2 cDNA, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?protein=P35354&geneProductId=UniProtKB:P35354
- ↑ ೨೨.೦ ೨೨.೧ Expression and localization of cyclooxygenase‐1 and ‐2 in human sporadic amyotrophic lateral sclerosis, GOA, ೯ ಮೇ 2019, P35354, UniProt, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, NAS
- ↑ Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2, GOA, ೯ ಮೇ 2019, P35354, UniProt, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, IDA
- ↑ ೨೪.೦ ೨೪.೧ British Heart Foundation, ೯ ಮೇ 2019, Human cyclooxygenase-2 cDNA, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354
- ↑ Expression and localization of cyclooxygenase‐1 and ‐2 in human sporadic amyotrophic lateral sclerosis, GOA, ೯ ಮೇ 2019, P35354, UniProt, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, IDA
- ↑ Parkinsons Disease Gene Ontology Initiative, ೯ ಮೇ 2019, Caveolin-1 interacts with Derlin-1 and promotes ubiquitination and degradation of cyclooxygenase-2 via collaboration with p97 complex, GOA, TAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354
- ↑ Mouse Genome Informatics, ೯ ಮೇ 2019, Cellular localization of cyclooxygenase-1 and cyclooxygenase-2 in the normal mouse, rat, and human retina, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354
- ↑ Parkinsons Disease Gene Ontology Initiative, ೯ ಮೇ 2019, Caveolin-1 interacts with Derlin-1 and promotes ubiquitination and degradation of cyclooxygenase-2 via collaboration with p97 complex, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354
- ↑ Human Protein Atlas, ೯ ಮೇ 2019, GOA, IDA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354
- ↑ ೩೦.೦ ೩೦.೧ ೩೦.೨ ೩೦.೩ ೩೦.೪ ೩೦.೫ Reactome, ೯ ಮೇ 2019, GOA, TAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354
- ↑ Hypoxia upregulates PGI-synthase and increases PGI₂ release in human vascular cells exposed to inflammatory stimuli, GOA, ೯ ಮೇ 2019, P35354, UniProt, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354, IEP
- ↑ ೩೨.೦ ೩೨.೧ British Heart Foundation, ೯ ಮೇ 2019, GOA, ISS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354
- ↑ ೩೩.೦ ೩೩.೧ British Heart Foundation, ೯ ಮೇ 2019, Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes, GOA, NAS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354
- ↑ ೩೪.೦ ೩೪.೧ ೩೪.೨ ೩೪.೩ ೩೪.೪ British Heart Foundation, ೯ ಮೇ 2019, Cyclooxygenase regulates angiogenesis induced by colon cancer cells, GOA, ISS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354
- ↑ British Heart Foundation, ೯ ಮೇ 2019, Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes, GOA, ISS, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354
- ↑ Gene Ontology Consortium, ೯ ಮೇ 2019, GOA, IEA, http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35354
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ೧೭ ಆಗಸ್ಟ್ 2016, 4139, ಆಂಗ್ಲ
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ೧೭ ಆಗಸ್ಟ್ 2016, 7124, ಆಂಗ್ಲ
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ೧೭ ಆಗಸ್ಟ್ 2016, 7141, ಆಂಗ್ಲ
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ೧೭ ಆಗಸ್ಟ್ 2016, 2892, ಆಂಗ್ಲ
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ೧೭ ಆಗಸ್ಟ್ 2016, 2714, ಆಂಗ್ಲ
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ೧೭ ಆಗಸ್ಟ್ 2016, 7185, ಆಂಗ್ಲ
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ೧೭ ಆಗಸ್ಟ್ 2016, 2896, ಆಂಗ್ಲ
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ೧೭ ಆಗಸ್ಟ್ 2016, 4194, ಆಂಗ್ಲ
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ೧೭ ಆಗಸ್ಟ್ 2016, 2713, ಆಂಗ್ಲ
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ೧೭ ಆಗಸ್ಟ್ 2016, 4795, ಆಂಗ್ಲ
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ೧೭ ಆಗಸ್ಟ್ 2016, 6661, ಆಂಗ್ಲ
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ೧೭ ಆಗಸ್ಟ್ 2016, 2897, ಆಂಗ್ಲ
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ೧೭ ಆಗಸ್ಟ್ 2016, 7219, ಆಂಗ್ಲ
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ೧೭ ಆಗಸ್ಟ್ 2016, 2593, ಆಂಗ್ಲ
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ೧೭ ಆಗಸ್ಟ್ 2016, 7220, ಆಂಗ್ಲ
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ೧೭ ಆಗಸ್ಟ್ 2016, 5230, ಆಂಗ್ಲ
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ೧೭ ಆಗಸ್ಟ್ 2016, 7401, ಆಂಗ್ಲ
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ೧೭ ಆಗಸ್ಟ್ 2016, 8976, ಆಂಗ್ಲ
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ೧೭ ಆಗಸ್ಟ್ 2016, 7252, ಆಂಗ್ಲ
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ೧೭ ಆಗಸ್ಟ್ 2016, 5239, ಆಂಗ್ಲ
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ೧೭ ಆಗಸ್ಟ್ 2016, 7270, ಆಂಗ್ಲ
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ೧೭ ಆಗಸ್ಟ್ 2016, 7273, ಆಂಗ್ಲ
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ೧೭ ಆಗಸ್ಟ್ 2016, 8741, ಆಂಗ್ಲ
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ೧೭ ಆಗಸ್ಟ್ 2016, 2893, ಆಂಗ್ಲ
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ೧೭ ಆಗಸ್ಟ್ 2016, 7298, ಆಂಗ್ಲ
- ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ೧೭ ಆಗಸ್ಟ್ 2016, 2894, ಆಂಗ್ಲ
- ↑ Open Targets Platform, ೧೪ ಆಗಸ್ಟ್ 2023, https://platform.opentargets.org/drug/CHEMBL154
- ↑ Open Targets Platform, ೧೪ ಆಗಸ್ಟ್ 2023, https://platform.opentargets.org/drug/CHEMBL1034
- ↑ Open Targets Platform, ೧೪ ಆಗಸ್ಟ್ 2023, https://platform.opentargets.org/drug/CHEMBL2107455
- ↑ Open Targets Platform, ೧೪ ಆಗಸ್ಟ್ 2023, https://platform.opentargets.org/drug/CHEMBL1071
- ↑ Open Targets Platform, ೧೪ ಆಗಸ್ಟ್ 2023, https://platform.opentargets.org/drug/CHEMBL1835207
- ↑ Open Targets Platform, ೧೪ ಆಗಸ್ಟ್ 2023, https://platform.opentargets.org/drug/CHEMBL25
- ↑ Open Targets Platform, ೧೪ ಆಗಸ್ಟ್ 2023, https://platform.opentargets.org/drug/CHEMBL521
- ↑ Open Targets Platform, ೧೪ ಆಗಸ್ಟ್ 2023, https://platform.opentargets.org/drug/CHEMBL166863
- ↑ Open Targets Platform, ೧೪ ಆಗಸ್ಟ್ 2023, https://platform.opentargets.org/drug/CHEMBL469
- ↑ Open Targets Platform, ೧೪ ಆಗಸ್ಟ್ 2023, https://platform.opentargets.org/drug/CHEMBL53292
- ↑ Open Targets Platform, ೧೪ ಆಗಸ್ಟ್ 2023, https://platform.opentargets.org/drug/CHEMBL139
- ↑ Open Targets Platform, ೧೪ ಆಗಸ್ಟ್ 2023, https://platform.opentargets.org/drug/CHEMBL622
- ↑ Open Targets Platform, ೧೪ ಆಗಸ್ಟ್ 2023, https://platform.opentargets.org/drug/CHEMBL1077
- ↑ Open Targets Platform, ೧೪ ಆಗಸ್ಟ್ 2023, https://platform.opentargets.org/drug/CHEMBL1297
- ↑ Open Targets Platform, ೧೪ ಆಗಸ್ಟ್ 2023, https://platform.opentargets.org/drug/CHEMBL898
- ↑ Open Targets Platform, ೧೪ ಆಗಸ್ಟ್ 2023, https://platform.opentargets.org/drug/CHEMBL435298
- ↑ Open Targets Platform, ೧೪ ಆಗಸ್ಟ್ 2023, https://platform.opentargets.org/drug/CHEMBL1200804
- ↑ Open Targets Platform, ೧೪ ಆಗಸ್ಟ್ 2023, https://platform.opentargets.org/drug/CHEMBL2103736
- ↑ Open Targets Platform, ೧೪ ಆಗಸ್ಟ್ 2023, https://platform.opentargets.org/drug/CHEMBL1201124
- ↑ Open Targets Platform, ೧೪ ಆಗಸ್ಟ್ 2023, https://platform.opentargets.org/drug/CHEMBL1200806
- ↑ Open Targets Platform, ೧೪ ಆಗಸ್ಟ್ 2023, https://platform.opentargets.org/drug/CHEMBL1200613
- ↑ Identifiers.org