ವಿಷಯಕ್ಕೆ ಹೋಗು

vemurafenib

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chemical compound

External resources

Freebase ಐಡಿ
/m/0hqvq1s[೧]
Reaxys registry number
12833468[೨]
PubChem CID
42611257[೩][೪]
MeSH descriptor ID
D000077484

subject named as: Vemurafenib

UniChem compound ID
649459[೫]
Quora topic ID
Vemurafenib[೬]
LiverTox ID
Vemurafenib
PDB ligand ID
032
KEGG ID
D09996[೨]
UNII
207SMY3FQT[೭][೪]
ATC code
L01XE15[೮]
DeCS ID
57657
PDB structure ID
3OG7[೯]
5HES[೧೦]
4RZV[೧೧]
OpenAlex ID
C2776131300[೧೨]
ChEMBL ID
CHEMBL1229517[೧೩]
DrugBank ID
DB08881[೪]
BBC Things ID
513b52df-f7fb-4032-9537-4d0e25ce26f0[೧೪]
InChIKey
GPXBXXGIAQBQNI-UHFFFAOYSA-N[೩][೧೫]
SPLASH
splash10-0006-0024900000-4911e6c7ad52fd2c2896
Human Metabolome Database ID
HMDB0259779[೧೬][೪]
CAS Registry Number
918504-65-1[೨][೧೭]
ChEBI ID
63637[೨][೧೮]

mapping relation type: exact match

WikiProjectMed ID
Vemurafenib
InChI
InChI=1S/C23H18ClF2N3O3S/c1-2-9-33(31,32)29-19-8-7-18(25)20(21(19)26)22(30)17-12-28-23-16(17)10-14(11-27-23)13-3-5-15(24)6-4-13/h3-8,10-12,29H,2,9H2,1H3,(H,27,28)[೩]
National Drug Code
50242-090
SureChEMBL ID
SCHEMBL298931[೪]
MeSH tree code
D02.065.884.919
D02.886.590.700.919
D03.633.100.473.936
Microsoft Academic ID
2776131300
Guide to Pharmacology Ligand ID
5893[೧೯]
HSDB ID
8143[೨೦]
UMLS CUI
C3192263
DSSTOX compound identifier
DTXCID00161201
PatientsLikeMe treatment ID
vemurafenib
ECHA Substance Infocard ID
100.287.801
MedlinePlus drug identifier
a612009
ChemSpider ID
24747352[೨೧]
EC number
850-250-7
NDF-RT ID
N0000183250[೨೨]
DrugCentral ID
4185[೫]
World Health Organisation international non-proprietary name numeric ID
9286
DSSTox substance ID
DTXSID50238710[೨೩][೪]
RxNorm ID
1147220
Probes And Drugs ID
PD003414

ಉದಾಹರಣೆಗೆ

type of chemical entity

ಉಪವರ್ಗ

ರಾಸಾಯನಿಕ ಸಂಯುಕ್ತ

ಬಳಕೆ

ಔಷಧ

chemical structure

mass

೪೮೯.೦೭೩ dalton[೩]

chemical formula

C₂₃H₁₈ClF₂N₃O₃S[೩]

canonical SMILES

CCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CNC3=NC=C(C=C23)C4=CC=C(C=C4)Cl)F[೩]

active ingredient in

Zelboraf[೨೪]

World Health Organisation international non-proprietary name

vemurafenib[೨]

medical condition treated

hairy cell leukemia[೨೫]
metastatic melanoma[೨೫]
ಚರ್ಮ ಕ್ಯಾನ್ಸರ್[೨೫]
Erdheim-Chester disease[೨೫]
melanoma[೨೫]

significant drug interaction

efavirenz[೨೬]

side effect: long QT syndrome

theophylline monohydrate[೨೬]

side effect: Achor-Smith syndrom

fosphenytoin[೨೬]

side effect: long QT syndrome

physically interacts with

B-Raf proto-oncogene, serine/threonine kinase[೨೭]

subject has role: enzyme inhibitor

Raf-1 proto-oncogene, serine/threonine kinase[೨೭]

subject has role: enzyme inhibitor

pregnancy category

Australian pregnancy category D
US pregnancy category D

LiverTox likelihood score

LiverTox toxicity likelihood category E*[೨೮]

subject has role

antineoplastic[೨೯]
protein kinase inhibitors[೩೦]
xenobiotic-transporting ATPase inhibitor[೩೦]
enzyme inhibitor[೨೯]

ಕಾಮನ್ಸ್ ವರ್ಗ

Vemurafenib

Reference

  1. ↑ Freebase Data Dumps, ೨೮ ಅಕ್ಟೋಬರ್ 2013
  2. ↑ ೨.೦ ೨.೧ ೨.೨ ೨.೩ ೨.೪ ChEBI, ೧೮ ಅಕ್ಟೋಬರ್ 2016, ಆಂಗ್ಲ, vemurafenib, 63637
  3. ↑ ೩.೦ ೩.೧ ೩.೨ ೩.೩ ೩.೪ ೩.೫ PubChem, ೧೮ ಅಕ್ಟೋಬರ್ 2016, ಆಂಗ್ಲ, 42611257, Vemurafenib
  4. ↑ ೪.೦ ೪.೧ ೪.೨ ೪.೩ ೪.೪ ೪.೫ GPXBXXGIAQBQNI-UHFFFAOYSA-N, InChIKey
  5. ↑ ೫.೦ ೫.೧ UniChem
  6. ↑ Quora
  7. ↑ Global Substance Registration System, ೧೮ ಅಕ್ಟೋಬರ್ 2016, ಆಂಗ್ಲ, vemurafenib, 207SMY3FQT
  8. ↑ DrugBank, ಆಂಗ್ಲ, ೧೭ ನವೆಂಬರ್ 2015, 08881, Vemurafenib
  9. ↑ Protein Data Bank, ೧೮ ಅಕ್ಟೋಬರ್ 2016, ಆಂಗ್ಲ, 3OG7, 3OG7
  10. ↑ Protein Data Bank, ೧೮ ಅಕ್ಟೋಬರ್ 2016, ಆಂಗ್ಲ, 5HES, 5HES
  11. ↑ Protein Data Bank, ೧೮ ಅಕ್ಟೋಬರ್ 2016, ಆಂಗ್ಲ, 4RZV, 4RZV
  12. ↑ OpenAlex, ೨೬ ಜನವರಿ 2022, https://docs.openalex.org/download-snapshot/snapshot-data-format
  13. ↑ ChEMBL, ೧೮ ಅಕ್ಟೋಬರ್ 2016, ಆಂಗ್ಲ, VEMURAFENIB, CHEMBL1229517
  14. ↑ BBC Things
  15. ↑ ChEBI release 2020-09-01
  16. ↑ inferred from InChIKey
  17. ↑ CAS Common Chemistry, ೮ ಏಪ್ರಿಲ್ 2021, https://commonchemistry.cas.org/detail?cas_rn=918504-65-1, GPXBXXGIAQBQNI-UHFFFAOYSA-N
  18. ↑ InChI=1S/C23H18ClF2N3O3S/c1-2-9-33(31,32)29-19-8-7-18(25)20(21(19)26)22(30)17-12-28-23-16(17)10-14(11-27-23)13-3-5-15(24)6-4-13/h3-8,10-12,29H,2,9H2,1H3,(H,27,28), International Chemical Identifier
  19. ↑ IUPHAR/BPS Guide to PHARMACOLOGY, ೧೮ ಅಕ್ಟೋಬರ್ 2016, ಆಂಗ್ಲ, 5893, vemurafenib
  20. ↑ Hazardous Substances Data Bank, ೧೦ ಮೇ 2021, ೨೮ ಅಕ್ಟೋಬರ್ 2019, Vemurafenib, 8143
  21. ↑ ChemSpider, ೧೮ ಅಕ್ಟೋಬರ್ 2016, ಆಂಗ್ಲ, 24747352, Vemurafenib
  22. ↑ NDF-RT, ೧೯ ಜನವರಿ 2016, ಆಂಗ್ಲ, VEMURAFENIB, N0000183250
  23. ↑ Mapping file of InChIStrings, InChIKeys and DTXSIDs for the EPA CompTox Dashboard
  24. ↑ RxNorm, 1147224, ೧೪ ಫೆಬ್ರವರಿ 2018
  25. ↑ ೨೫.೦ ೨೫.೧ ೨೫.೨ ೨೫.೩ ೨೫.೪ Drug Indications Extracted from FAERS, ೨ ಅಕ್ಟೋಬರ್ 2018
  26. ↑ ೨೬.೦ ೨೬.೧ ೨೬.೨ A reference set of clinically relevant adverse drug-drug interactions, hypothetically
  27. ↑ ೨೭.೦ ೨೭.೧ IUPHAR/BPS Guide to PHARMACOLOGY, ೧೭ ಆಗಸ್ಟ್ 2016, 5893, ಆಂಗ್ಲ
  28. ↑ LiverTox, ೮ ಏಪ್ರಿಲ್ 2021, https://www.ncbi.nlm.nih.gov/books/n/livertox/Vemurafenib, ೨೮ ಜೂನ್ 2018
  29. ↑ ೨೯.೦ ೨೯.೧ Medical Subject Headings, ೧೫ ಮಾರ್ಚ್ 2018, C551177
  30. ↑ ೩೦.೦ ೩೦.೧ N0000183250, ೫ ಮಾರ್ಚ್ 2018, NDF-RT
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